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Incretin effects in the human pancreas

8 April 2013 - Editor's Corner

Exposure to incretin therapy has been reported to show proliferative effects on both the endocrine and exocrine pancreas in some animal models. Alex Butler and colleagues now provide the first description of human pancreas derived from donors on incretin based therapy and report increased pancr(...) Read more

Troubles ahead for the incretin therapies?

29 March 2013 - Hot Topics

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Screening for diabetes is probably useless

8 December 2012 - Medical Journals

Given the increasing prevalence of diabetes and the possible benefits of early diabetes treatment, population screening has been under consideration in many countries. However, Simmons and colleagues demonstrate that even when limiting screening to a high risk population there is no ultimate be(...) Read more

Too much of a good thing: further evidence for the harm of dual RAAS blockade

6 November 2012 - Medical Journals, Drug Watch

Inhibition of the renin-angiotensin aldosteron system through the use of Angiotensin Converting Enzyme (ACE) Inhibitors has been a major advance in the prevention of cardiovascular and renal complications in diabetes. The ACE-inhibitors were followed by Angiotensin Receptor Blockers (ARBs) and (...) Read more

ORIGIN: no demonstrable benefits, yet beneficial.

18 September 2012 - Medical Journals, Drug Watch

These days, many of us seem to feel that every new large trial brings new disappointment. Following VADT, ADVANCE and ACCORD, many may have anticipated the negative results of ORIGIN (N Engl J Med 2012; 367:319-328) and the question arises whether any of the currently running large ‘hard-endpoi(...) Read more

It’s not at all about exercising; it’s about not exercising at all.

18 September 2012 - Medical Journals

As highlighted in a recent Lancet Series issue (2012; Volume 380, Issue 9838) a lack of exercise is a major threat to global health. A systematic review and meta-analysis now published by Wilmot and colleagues in Diabetologia lends further support to the notion that it is not so much serious ex(...) Read more