This entry provides a simple listing of some important dates in the history of diabetes from 1950-2000, described in more detail in the accompanying article. So much happened over this period that important dates have undoubtedly been omitted: readers are invited to add to the list.
1951: Primary sequence of bovine insulin determined by Frederick Sanger
1956: Bromer deduces the molecular sequence of glucagon.
1958: Tolbutamide, the first oral (sulfonylurea) treatment for diabetes
1962: Radioimmunoassay of insulin by Berson and Yalow
1966: Introduction of the biguanides phenformin (later withdrawn) and metformin
1967: Proinsulin and C-peptide identified by Don Steiner
1969: Tertiary structure of insulin determined by Dorothy Hodgkin 1969: First results from UGDP
1974: Islet cell antibodies described by Franco Bottazzo HLA associations of juvenile diabetes described by Jørn Nerup
1976: The terms type 1 & type 2 diabetes are reintroduced by Andrew Cudworth
1977: First paper on HbA1c and glucose control in diabetes
1978: First papers on home blood glucose monitoring published
1979: Creutzfeldt reintroduces the incretin concept
1980: Structure of the insulin gene published by David Owerbach and co-workers
1982: Biosynthetic human insulin produced.
1992: Glucokinase gene mutations linked to type 2 diabetes and MODY 1992: First clinical studies with GLP-1
1993: Publication of DCCT results
1996: Insulin lispro becomes the first insulin analogue to be marketed
1997: Launch of troglitazone, the first thiazolidinedione, later withdrawn
1998: Publication of UKPDS results